H2N2V1, Main, Exploration, bibRecord, 001975

Independence of Evolutionary and Mutational Rates after Transmission of Avian Influenza Viruses to Swine

Identifieur interne : 001975 ( Main/Exploration ); précédent : 001974; suivant : 001976

Independence of Evolutionary and Mutational Rates after Transmission of Avian Influenza Viruses to Swine

Auteurs : J. Stech ; X. Xiong ; C. Scholtissek ; R. G. Webster

Source :

Journal of Virology [ 0022-538X ] ; 1999.

RBID : PMC:104428

Descripteurs français

KwdFr :
- Animaux, Chiens, Infections à Orthomyxoviridae (transmission), Mutation, Réplication virale, Suidae (virologie), Virus de la grippe A (), Virus de la grippe A (génétique), Évolution biologique.
MESH :
- génétique : Virus de la grippe A.
- virologie : Suidae.
- Animaux, Chiens, Infections à Orthomyxoviridae, Mutation, Réplication virale, Virus de la grippe A, Évolution biologique.

English descriptors

KwdEn :
- Animals, Biological Evolution, Dogs, Influenza A virus (classification), Influenza A virus (genetics), Mutation, Orthomyxoviridae Infections (transmission), Swine (virology), Virus Replication.
MESH :
- classification : Influenza A virus.
- genetics : Influenza A virus.
- transmission : Orthomyxoviridae Infections.
- virology : Swine.
- Animals, Biological Evolution, Dogs, Mutation, Virus Replication.

Abstract

In 1979, an H1N1 avian influenza virus crossed the species barrier, establishing a new lineage in European swine. Because there is no direct or serologic evidence of previous H1N1 strains in these pigs, these isolates provide a model for studying early evolution of influenza viruses. The evolutionary rates of both the coding and noncoding changes of the H1N1 swine strains are higher than those of human and classic swine influenza A viruses. In addition, early H1N1 swine isolates show a marked plaque heterogeneity that consistently appears after a few passages. The presence of a mutator mutation was postulated (C. Scholtissek, S. Ludwig, and W. M. Fitch, Arch. Virol. 131:237–250, 1993) to account for these observations and the successful establishment of an avian H1N1 strain in swine. To address this question, we calculated the mutation rates of A/Mallard/New York/6750/78 (H2N2) and A/Swine/Germany/2/81 (H1N1) by using the frequency of amantadine-resistant mutants. To account for the inherent variability of estimated mutation rates, we used a probabilistic model for the statistical analysis. The resulting estimated mutation rates of the two strains were not significantly different. Therefore, an increased mutation rate due to the presence of a mutator mutation is unlikely to have led to the successful introduction of avian H1N1 viruses in European swine.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC104428

PubMed: 9971766
PubMed Central: 104428

Affiliations:

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Independence of Evolutionary and Mutational Rates after Transmission of Avian Influenza Viruses to Swine

Independence of Evolutionary and Mutational Rates after Transmission of Avian Influenza Viruses to Swine

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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